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زیست شناسی::
لنفوسیت معیوب
IRAK IL-1 Receptor-associated Kinase
Crystals of alum and urea stimulate the Nod-like receptor (NLR) inflammasome system in the cytoplasm, and NLR activation induces IL-1ک and IL-18 in myeloid cells.
IL-1 receptor also recruits MyD88 to signal for the activation of NF-?
On the other hand, production of NALP3 and preform of IL-1ک/IL-18 are upregulated by MyD88 signaling of TLR4.
The caspase 1 initiates active IL-1ک/IL-18 production.
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